Professor Yuhao Li | SITCM – Explore Your Future

Professor Yuhao Li

Professor Yuhao Li

HE Academic Staff

Title:

Brief Qual PhD, MMed, BMed
Position Head of Research
Phone +61 2 9212 1968
Email yuhao@sitcm.edu.au
Postal Address PO Box K623, Haymarket 2000
Summary Prof. Yuhao Li was a Senior Research Fellow and the head of Endocrinology and Metabolism of Faculty of Pharmacy at the University of Sydney. He had also been research fellow and the Head of Laboratory of the Department of Endocrinology and Metabolism at the Kyoto University Hospital (Japan). During his position at the University of Sydney, Prof Li has established the Endocrinology and Metabolism Group, and organised the following projects: a. the metabolic syndrome and diabetes-related complications, and beneficial effects of traditional herbs; b. Panax notoginseng for the management of dietary hyperlipidemia and diabetes-related cardiac complications. As the corresponding author, Prof. Li has obtained over 10 sound international publications. Recently, Prof. Li has been developing and conducting research projects at SITCM with funds granted by the R&D Agency for Curative Natural Products (a Japanese government-registered non-profit organization). His research interests are in Pathophysiology, prevention and treatment of metabolic syndrome, diabetes and cardiovascular diseases with Chinese medicines.
Academic & Professional Qualifications:
  • 1999: PhD (Endocrinology and Metabolism), Kyoto Pharmaceutical University, Japan
  • 1987: Master of Medicine, Guangzhou University of Chinese Medicine, China·
  • 1984: Bachelor of Medicine, Guangzhou University of Chinese Medicine, China
Teaching Experience:
  • 2012 – present: Lecturer, SITCM·       2002 – 2012: Senior Lecturer of Endocrinology and Metabolism, Faculty of Pharmacy, University of Sydney·       2007 – 2011: Senior Research Fellow and Head of Laboratory, Kyoto University Hospital, Japan
  • 2002 – 2011: Pharmacology of Herbal Medicines, The Herbal Medicine Research and Education Centre, University of Sydney
  • 1997 – 2002: Basics of Traditional Chinese Medicine, Science of Chinese Medicine, and Internal Medicine of Traditional Chinese Medicine, Japanese Association of Traditional Chinese Medicine, Japan
  • 1995 – 1996: Lecturer, Associate Professor and Head of Department of Pharmacology of Chinese Medicine, Guangzhou University of Chinese Medicine, China.
  • 1987 – 1996: Pharmacology of Chinese Medicines and Science of Chinese Medicines, Guangzhou University of Chinese Medicine, China.
Relevant Employment/Experience:
  • Feb 2012 – present: Head of Research Team, Sydney Institute of Traditional Chinese Medicine
  • Apr 2002 – present: Senior Lecturer of Endocrinology and Metabolism, Faculty of Pharmacy, University of Sydney
  • Feb 2007 – Apr 2011: Senior Research Fellow and Head of Laboratory, Kyoto University Hospital, Japan
  • Mar 1995 – Sep 1996: Lecturer, Associate Professor and Head of Department of Pharmacology of Chinese Medicine, Consulting Doctor, Guangzhou University of Chinese Medicine, China
Professional and/or Honorary Memberships:
  • 2013 – present: The Council Member of the 3rd Board of Specialty Committee of Diabetes of World Federation of Chinese Medicine Societies
  • 2012 – present: The Council Member of the 2nd Board of Specialty Committee of TCM Pharmacology of World Federation of Chinese Medicine Societies·
  • 2004 – present: Member of the Australian Acupuncture and Chinese Medicine Association
  • 1996: Member of Pharmacist of Chinese Medicines, 1996.
Publications:
Journals
  • RECENT PUBLICATIONS (from a total of 102)1)      Zhao Y, Pan Y, Yang Y, Batey R, Wang J, Li Y* (2015). Treatment of rats with Jiangzhi Capsule improves liquid fructose-induced fatty liver: modulation of hepatic expression of SREBP-1c and DGAT-2. Journal of Translational Medicine. 13:174 (*the corresponding author).2)
  • Xing X, Li D, Chen D, Zhou L, Chonan R, Yamahara J, Wang J, Li Y* (2014). Mangiferin treatment inhibits hepatic expression of acyl-coenzyme A:diacylglycerol acyltransferase-2 in fructose-fed spontaneously hypertensive rats: a link to amelioration of fatty liver. Toxicology and Applied Pharmacology. 280(2):207-215 (*the corresponding author).
  • Yang M, Liu C, Jiang J, Zuo G, Lin X, Yamahara J, Wang J, Li Y* (2014). Ginger supplement protects rat from fructose-induced tubulointerstitial injury in the kidney through suppression of renal expression of proinflammatory cytokines. BMC Complementary and Alternative Medicine. 14:174 (*the corresponding author).
  • Li Y, Wang J, Gu T, Yamahara J, Li Y* (2014). Oleanolic acid supplement attenuates liquid fructose-induced adipose tissue insulin resistance through the insulin receptor substrate-1/phosphatidylinositol 3-kinase/Akt signaling pathway in rats. Toxicology and Applied Pharmacology.   277:155-163 (*the corresponding author).
  • Liu L, Yang M, Lin X, Li Y, Liu C, Yang Y, Yamahara J, Wang J, Li Y* (2013). The hepatic sterol regulatory element-binding protein-1c is an important molecular target for Salacia oblonga root in the improvement of fructose-induced fatty liver in rats. Journal of Ethnopharmacology 150:1645-1052 (*the corresponding author).
  • Liu C, Li Y, Zuo G, Xu W, Gao H, Yang Y, Yamahara J, Wang J, Li Y* (2013). Oleanolic acid diminishes liquid fructose-induced fatty liver in rats: role of modulation of hepatic sterol regulatory element-binding protein-1c-mediated expression of genes responsible for de novo fatty acid synthesis. Evidence-Based Complementary and Alternative Medicine. 2013: 534084 (*the corresponding author).
  • Wang J*, Gao H, Ke D, Zuo G, Yang Y, Yamahara J, Li Y* (2013). Improvement of liquid fructose-induced adipose tissue insulin resistance by ginger treatment in rats is associated with suppression of adipose macrophage-related pro-inflammatory cytokines. Evidence-Based Complementary and Alternative Medicine. 2013:590376 (*the corresponding author).
  • Gao H, Guan T, Li C, Zuo G, Yamahara J, Wang J, Li Y* (2012). Treatment with ginger ameliorates fructose-induced fatty liver and hypertriglyceridemia in rats: modulation of the hepatic carbohydrate response element binding protein-mediated pathway. Evidence-Based Complementary and Alternative Medicine. 2012:570948 (*the corresponding author).
  • Kam A, Li KM, Razmovski-Naumovski, Nammi S, Chan K, Li Y, Li GQ (2012). The protective effects of natural products on blood-brain barrier breakdown. Current Medicinal Chemistry 19:1830-1845.Wang J, Rong X, Li W, Yamahara J, Li Y* (2012). Rhodiola crenulata root ameliorates derangements of glucose and lipid metabolism in a rat model of the metabolic syndrome and type 2 diabetes. Journal of Ethnopharmacology 142:782-788 (*the corresponding author).
  • Wang J, Rong X, Li W, Yamahara J, Li Y* (2012). Salacia oblonga ameliorates endogenous hypertriglyceridemia and excessive ectopic fat accumulation in laying hens. Journal of Ethnopharmacology 142:221-227 (*the corresponding author).
  • Wang J, Rong X, Um ISI, Yamahara J, Li Y* (2011). 55-Week treatment of mice with the Unani and Ayurvedic medicine pomegranate flower ameliorates ageing-associated insulin resistance and skin abnormalities. Evidence-Based Complementary and Alternative Medicine 2012:350125 (*the corresponding author).
  • Zhao M, Li Y*, Wang J, Ebihara K, Rong X, Hosoda K, Tomita T, Nakao K (2011). Azilsartan treatment improves insulin sensitivity in obese spontaneously hypertensive Koletsky rats. Diabetes Obes Metab. 13:1123-1129 (*the corresponding author).
  • He L, Qi Y, Jiang J, Yang Q, Yamahara J, Murray M, Li Y* (2011). The Ayurvedic medicine Salacia oblonga attenuates diabetic renal fibrosis in rats: suppression of angiotensin II/AT1 signaling. Evidence-Based Complementary and Alternative Medicine 2011:807451. (*the corresponding author).
  • Rong X, Li Y*, Ebihara K, Zhao M, Kusakabe T, Tomita T, Murray M, Nakao K (2010). Irbesartan treatment upregulates hepatic expression of PPARalpha and its target genes in obese Koletsky (fak/fak) rats: a link to amelioration of hypertriglyceridemia Br J Pharmacol 160:1796-807. (*the corresponding author).
  • Rong X, Li Y *, Ebihara K, Zhao M, Naowaboot J, Kusakabe T, Kuwahara K, Murray, M, Nakao K (2010). Angiotensin II type 1 receptor-independent benefit effects of telmisartan on dietary-induced obesity, insulin resistance and fatty liver in mice. Diabetologia 53:1727-1731. (*the corresponding author).
  • Li Y*, Saito Y, Kuwahara K, Rong X, Kishimoto I, Harada M, Horiuchi H, Murray M, Nakao K (2010). Vasodilator therapy with hydralazine induces AT2 receptor-mediated cardiomyocyte growth in mice lacking guanylyl cyclase-A. Br J Pharmacol 159:1133-42. (*the corresponding author).
  • Kinoshita H, Kuwahara K, Nishida M, Jian Z, Rong X, Kiyonaka S, Kuwabara Y, Kurose H, Inoue R, Mori Y, Li Y, Nakagawa Y, Usami S, Fujiwara M, Yamada Y, Minami T, Ueshima K, Nakao K (2010). Inhibition of TRPC6 channel activity contributes to the antihypertrophic effects of natriuretic peptides-guanylyl cyclase-A signaling in the heart. Circ Res106:1849-1860.
  • Rong X, Li Y*, Ebihara K, Zhao M, Aini W, Kusakabe T, Hirata M, Miyamoto L, Nakao K (2009). An adipose tissue-independent insulin-sensitizing action of telmisartan: a study in lipodystrophic mice. J Pharmacol Exp Ther 331:1096-1103. (*the corresponding author).
  • Li Y*, Saito Y, Kuwahara K, Rong X, Kishimoto I, Harada M, Adachi Y, Nakanishi M, Kinoshita H, Horiuchi H, Murray M, Nakao K (2009). Guanylyl cyclase-A inhibits angiotensin II type 2 receptor-mediated pro-hypertrophic signaling in the heart. Endocrinology 150:3759-3765 (*the corresponding author).
  • Rong X, Peng G, Suzuki T, Yang Q, Yamahara J, Li Y* (2009) A 35-day gavage safety assessment of ginger in rats. Regulatory Toxicology and Pharmacology 54:118-123 (*the corresponding author)
  • Xu KZY, Zhu C, Yamahara J, Li Y* (2009). Pomegranate flower ameliorates fatty liver in an animal model of type 2 diabetes and obesity: upregulation of hepatic expression of genes responsible for fatty acid oxidation. Journal of Ethnopharmacology 123:280-287 (*the corresponding author).
  • He L, Rong X, Jiang JM, Liu PQ, Li Y* (2008). Amelioration of anti-cancer agent adriamycin-induced nephrotic syndrome in rats by Wulingsan (Gorei-San), a blended traditional Chinese herbal medicine. Food and Chemical Toxicology 46:1452-60. (*the corresponding author).
  • Salam NK, Huang TH, Kota BP, Kim MS, Li Y, Hibbs DE (2008). Novel PPAR-gamma agonists identified from a natural product library: a virtual screening, induced-fit docking and biological assay study. Chemical Biology & Drug Design 71:57-70.
  • Li Y*, Qi Y, Kim MS, Xu KZ, Huang THW, Rong X, Murray M, Yamahara J (2008). Increased renal collagen cross-linking and lipid accumulation in nephropathy of Zucker diabetic fatty rats. Diabetes-metabolism Research and Reviews 24:498-506. (*the corresponding author).
  • Rong X, Kim MS, Su N, Wen S, Matsuo Y, Yamahara J, Murray M, Li Y* (2008). An aqueous extract of Salacia oblonga root, a herb-derived peroxisome proliferator-activated receptor-alpha activator, by oral gavage over 28 days induces gender-dependent hepatic hypertrophy in rats. Food and Chemical Toxicology 46:2165-2172. (*the corresponding author).
  • Li Y*, Huang TH, Yamahara J (2008). Salacia root, a unique Ayurvedic medicine, meets multiple targets in diabetes and obesity. Life Sciences 82:1045-1049. (*the corresponding author).
  • Huang TH, He L, Qin Q, Yang Q, Peng P, Harad M, Qi Y, Yamahara J, Roufogalis BD, Li Y* (2008). Salacia oblonga root decreases cardiac hypertrophy in Zucker diabetic fatty rats: inhibition of cardiac expression of angiotensin II type 1 receptor. Diabetes Obesity & Metabolism 10:574-585. (*the corresponding author).
  • Li Y*, Qi Y, Huang TH., Yamahara J, Roufogalis BD (2008). Pomegranate flower: a unique traditional anti-diabetic medicine with dual PPAR-alpha/gamma activator properties (a review). Diabetes, Obesity & Metabolism 10:10-17. (*the corresponding author).
  • Wen S, Li Y (2008). Drug-Chinese herb Interaction Guide. PART II. Journal of Complementary Medicine July/August, 75-80.
  • Wen S, Li Y (2008) Drug-Chinese herb Interaction Guide. PART I. Journal of Complementary Medicine May/June, 72-77
  • Yang Q, Li Y (2007). Roles of PPARs on regulating myocardial energy and lipid homeostasis. Journal of Molecular Medicine-JMM 85:697-706.
  • Huang TH, Tran VH, Roufogalis BD, Li Y (2007). Gypenoside XLIX, a naturally occurring gynosaponin, PPAR-alpha dependently inhibits LPS-induced tissue factor expression and activity in human THP-1 monocytic cells. Toxicology and Applied Pharmacology 218:30-36. (*the corresponding author).
  • Huang TH, Tran VH, Roufogalis BD, Li Y (2007). Gypenoside XLIX, a naturally occurring PPAR-alpha activator, inhibits cytokine-induced vascular cell adhesion molecule-1 expression and activity in human endothelial cells. European Journal of Pharmacology 565:158-165. (*the corresponding author).

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