July 22, 2019

General Information
Duration 1 semester
Level Year 2, Semester 1
Unit Weighting Unit Credit Points: 10 credit points
Total Course Credit Points: 320 credit points
Student Workload Number of timetabled hours per week: 4
Number of personal study hours per week: 6
Total workload hours per week: 10
Prerequisites HMS105: Human Anatomy 2 & Physiology
Academic Details
Description This unit introduces students to pathology. Students will study the causal factors in disease, disease processes and bodily responses. This will include the processes of cell damage and necrosis, inflammation and healing. The causes of genetically determined and acquired diseases will be examined and the roles of physical agents, chemical poisons, nutritional deficiencies, infections and infestations, abnormal immunological responses, and psychological factors will be identified. The common diseases of each bodily system will be examined including aetiological factors, pathogenesis, diagnostic features, prognosis and sequelae. Furthermore, the importance and common topics of environmental pathology will be introduced.
Learning outcomes On successful completion of this unit students will be able to:
a. Describe the classifications and common causes of human diseases.
b. Analyse the aetiology, pathogenesis and clinical manifestations of common diseases including the diseases of cardiovascular, respiratory, gastrointestinal, hepatobiliary and pancreatic, urogenital, nervous, integumentary, haematological and endocrine systems, and the disorders of the ear and eyes.
c. Investigate the responses of the body to injury and the role of immunological responses in the disease process.
d. Appraise the pathogenesis, symptomatology and control of viral, bacterial, fungal, protozoal and parasitic diseases.
e. Analyse the aetiology, pathogenesis and symptomatology of neoplasia, circulatory dysfunction, chromosomal and genetic abnormalities.
Assessment Quiz (10%)
Practical activity: Slide Reading (30%)
Research Assignment (30%)
Group Presentation (30%)
Prescribed Textbooks/Readings * The prescribed and recommended readings are subject to annual review.

Alston, C. L., Rocha, M. C., Lax, N. Z., Turnbull, D. M., & Taylor, R. W. (2017). The genetics and pathology of mitochondrial diseases: Mitochondrial genetic disease. The Journal of Pathology, 241(2), 236-250. doi: 10.1002/path.4809

Amagai, M. (2016). Modulating immunity to treat autoimmune disease. The New England Journal of Medicine, 375(15), 1487-1489. doi: 10.1056/NEJMcibr1608900

Gomez-Salinero, J. M., & Rafii, S. (2018). Endothelial cell adaptation in regeneration. Science (New York, N.Y.), 362(6419), 1116-1117. doi: 10.1126/science.aar4800

Guarner, J. (2014). Incorporating pathology in the practice of infectious disease: Myths and reality. Clinical Infectious Diseases, 59(8), 1133-1141. doi: 10.1093/cid/ciu469

Kumar, V., Abbas, A. K., Aster, J. C. (2017). Robbins Basic Pathology (10th ed.). Philadelphia, PA: Elsevier/Saunders

O’Farrell, S., Sandström, K., Garmo, H., Stattin, P., Holmberg, L., Adolfsson, J., & Van Hemelrijck, M. (2016). Risk of thromboembolic disease in men with prostate cancer undergoing androgen deprivation therapy. BJU International118(3), 391–398. doi:10.1111/bju.13360